Neurofluidic Exoskeletons for Adaptive Gait Rehabilitation: A Translational Perspective

Authors

DOI:

https://doi.org/10.63501/jvvknn95

Keywords:

Rehabilitation, healthcare, gait retraining

Abstract

Neurofluidic exoskeletons are a revolutionary innovation for gait retraining of individuals with neurological impairments, such as stroke or multiple sclerosis. These fluid-based devices adjust according to patient progress and can provide personalized torque and timing for smoother and more natural movement than traditional, rigid exoskeletons. Recent studies report that exoskeleton-assisted gait training improves gait function and lower limb strength in subacute stroke patients. In contrast, enhanced neuroplasticity appears to arise from the intervention through the use of adaptive control algorithms. However, issues such as device miniaturization, the ease with which devices can be fitted, and equitable access still need to be pondered. Other large-scale studies are needed to establish the long-term effectiveness and cost-benefits. The present commentary argues that the neurofluidic exoskeletons can make a paradigm shift in neurorehabilitation and notes the need for further inquiry and policy mechanisms for integrating these technologies into clinical practice to improve mobility and the quality of life.

References

1. Chang WH, Kim TW, Kim HS, Hanapiah FA, Lee JW, Han SH, et al. Interim results of exoskeletal wearable robot for gait recovery in subacute stroke patients. Sci Rep. 2025 Apr 5;15(1):11671. doi:10.1038/s41598-025-96084-6.

2. Li Y, Zhang B, Wang L, et al. Adaptive gait training of a lower limb rehabilitation robot based on patient performance. Cyborg Bionic Syst. 2024;4(1):0115. doi:10.34133/cbsystems.0115.

3. Wang Z, Liu Y, Huang Q, et al. Active gait retraining with lower limb exoskeleton based on robust inner and outer loop controller. Appl Sci. 2025;15(7):4032. doi:10.3390/app15074032.

4. Lejeune T, Nuic D, Dehem S, Previnaire JG, Cuenot C, Debugne T, et al. Hands-free Atalante exoskeleton in post-stroke gait and balance rehabilitation: a safety study. J Neuroeng Rehabil. 2025 Apr 12;22(1):82. doi:10.1186/s12984-025-01621-z.

5. Piloting a powered exoskeleton for gait training in multiple sclerosis. Consult QD. Cleveland Clinic. 2025.

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Published

2025-05-29

Issue

Section

⁠Brief Report / Short Communication

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