Fatherhood Begins Before Conception - How Epigenetics Is Rewriting the Story of Paternal Inheritance

Authors

DOI:

https://doi.org/10.63501/j7k7hj32

Keywords:

Epigenetics, Genetic, Spermatozoa, Preconception Care, Lifestyle

References

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Donkin, I., & Barrès, R. (2018). Sperm epigenetics and influence of environmental factors. Molecular Metabolism, 14, 1–11. https://doi.org/10.1016/j.molmet.2018.02.006

Feinberg, A. P. (2018). The key role of epigenetics in human disease prevention and mitigation. New England Journal of Medicine, 378(14), 1323–1334. https://doi.org/10.1056/NEJMra1402513

Fullston, T., Ohlsson Teague, E. M. C., Palmer, N. O., DeBlasio, M. J., Mitchell, M., Corbett, M., Print, C. G., Owens, J. A., & Lane, M. (2013). Paternal obesity initiates metabolic disturbances in two generations of mice with incomplete penetrance to the F2 generation and alters the transcriptional profile of testis and sperm microRNA content. FASEB Journal, 27(10), 4226–4243. https://doi.org/10.1096/fj.12-224048

Heard, E., & Martienssen, R. A. (2014). Transgenerational epigenetic inheritance: Myths and mechanisms. Cell, 157(1), 95–109. https://doi.org/10.1016/j.cell.2014.02.045

Jenkins, T. G., & Carrell, D. T. (2012). The sperm epigenome and potential implications for the developing embryo. Reproduction, 143(6), 727–734. https://doi.org/10.1530/REP-11-0450

Ng, S.-F., Lin, R. C. Y., Laybutt, D. R., Barres, R., Owens, J. A., & Morris, M. J. (2010). Chronic high-fat diet in fathers’ programs β-cell dysfunction in female rat offspring. Nature, 467(7318), 963–966. https://doi.org/10.1038/nature09491

Pembrey, M. E., Bygren, L. O., Kaati, G., Edvinsson, S., Northstone, K., Sjöström, M., & Golding, J. (2006). Sex-specific, male-line transgenerational responses in humans. European Journal of Human Genetics, 14(2), 159–166. https://doi.org/10.1038/sj.ejhg.5201538

Rodgers, A. B., Morgan, C. P., Bronson, S. L., Revello, S., & Bale, T. L. (2013). Paternal stress exposure alters sperm microRNA content and reprograms offspring HPA stress axis regulation. Journal of Neuroscience, 33(21), 9003–9012. https://doi.org/10.1523/JNEUROSCI.0914-13.2013

Soubry, A. (2018). POHaD: Why we should study future fathers. Environmental Epigenetics, 4(2), dvy007. https://doi.org/10.1093/eep/dvy007

Soubry, A., Schildkraut, J. M., Murtha, A., Wang, F., Huang, Z., Bernal, A., Kurber, J., Jirtle, R. L., Murphy, S. K., & Hoyo, C. (2013). Paternal obesity is associated with IGF2 hypomethylation in newborns: Results from a Newborn Epigenetics Study (NEST) cohort. BMC Medicine, 11, 29. https://doi.org/10.1186/1741-7015-11-29

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Published

2026-03-24

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Section

⁠Commentary / Perspective / Opinion

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