Ionic Microdomains as Emerging Determinants of Compensatory Nephron Hypertrophy: A Paradigm Shift in Renal Cellular Signaling

Authors

DOI:

https://doi.org/10.63501/w0pjbn38

Keywords:

Ionic Microdomains, Compensatory Nephron Hypertrophy, Renal Cellular Signaling‎, mTOR‎, MAPK

Author Biographies

  • Karan Chaman Lal, Liaquat University of Medical & Health Sciences

    Department of Medicine

  • Ayesha Ubaid Ullah‎, Islamic International Medical College‎

    Department of Medicine

  • Mishal Iqbal, Islamic International Medical College‎

    Department of Medicine

  • Zainab Binte Tahir, Islamic International Medical College‎

    Department of Medicine

  • Jepal Kumar, Liaquat University of Medical & Health Sciences

    Department of Medicine

References

‎1.‎ McArdle Z, Schreuder MF, Moritz KM, Denton KM, Singh RR. Physiology ‎and Pathophysiology of Compensatory Adaptations of a Solitary Functioning Kidney. ‎Front Physiol [Internet]. 2020 Jun 26 [cited 2025 Oct 28];11:725. Available from: ‎https://pmc.ncbi.nlm.nih.gov/articles/PMC7332829/‎

‎2.‎ Al-Awqati Q. Kidney growth and hypertrophy: the role of mTOR and vesicle ‎trafficking. J Clin Invest [Internet]. 2015 Jun 1 [cited 2025 Oct 28];125(6):2267. ‎Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC4497766/‎

‎3.‎ Kikuchi H, Chou CL, Yang CR, Chen L, Jung HJ, Park E, et al. Signaling mechanisms ‎in renal compensatory hypertrophy revealed by multi-omics. Nat Commun [Internet]. ‎‎2023 Dec 1 [cited 2025 Oct 28];14(1). Available from: ‎https://pubmed.ncbi.nlm.nih.gov/37328470/‎

‎4.‎ Tanaka S, Fujio Y, Nakayama H. Caveolae-specific CaMKII signaling in the regulation ‎of voltage-dependent calcium channel and cardiac hypertrophy. Front Physiol [Internet]. ‎‎2018 Aug 7 [cited 2025 Oct 28];9(AUG):391436. Available from: ‎https://doi.org/10.1080/15548627.2015.1052208‎

‎5.‎ Ning B, Guo C, Kong A, Li K, Xie Y, Shi H, et al. Calcium Signaling Mediates Cell ‎Death and Crosstalk with Autophagy in Kidney Disease. Cells 2021, Vol 10, Page 3204 ‎‎[Internet]. 2021 Nov 17 [cited 2025 Oct 28];10(11):3204. Available from: ‎https://www.mdpi.com/2073-4409/10/11/3204/htm‎

‎6.‎ Chen JK, Nagai K, Chen J, Plieth D, Hino M, Xu J, et al. Phosphatidylinositol 3-kinase ‎signaling determines kidney size. J Clin Invest [Internet]. 2015 Jun 1 [cited 2025 Oct ‎‎28];125(6):2429–44. Available from: https://pubmed.ncbi.nlm.nih.gov/25985273/‎

‎7.‎ Denic A, Alexander MP, Kaushik V, Lerman LO, Lieske JC, Stegall MD, et al. ‎Detection and Clinical Patterns of Nephron Hypertrophy and Nephrosclerosis Among ‎Apparently Healthy Adults. Am J Kidney Dis [Internet]. 2016 Jul 1 [cited 2025 Oct ‎‎28];68(1):58. Available from: https://pmc.ncbi.nlm.nih.gov/articles/PMC4921258/‎

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Published

2026-03-24

Issue

Vol. 2 No. 1 (2026): Spring

Section

⁠Letters to the Editor

License

This article is licensed under a Creative Commons Attribution 4.0 International License (CC BY 4.0), which permits use, sharing, adaptation, distribution, and reproduction in any medium or format, provided appropriate credit is given to the author(s) and the source. To view a copy of this license, visit: https://creativecommons.org/licenses/by/4.0

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